The binding of thiopentone to kwashiorkor serum.
نویسندگان
چکیده
The binding of thiopentone to normal and kwashiorkor serum has been investigated. It has been confirmed that thiopentone is bound to albumin predominantly. In kwashiorkor serum, less binding to albumin occurs, but secondary binding sites appear. The significance of these observations is discussed.
منابع مشابه
Pharmacokinetics of thiopentone enantiomers following intravenous injection or prolonged infusion of rac-thiopentone.
AIMS Thiopentone is administered as a racemate (rac-thiopentone) for induction of anaesthesia as well as for neurological and neurosurgical emergencies. The pharmacokinetics and pharmacodynamics of rac-thiopentone have been extensively studied but the component R-(+)- and S-(-)- enantiomers, until very recently, have been largely ignored. METHODS The present study analyses the pharmacokinetic...
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Background: Induction of anesthesia in patients that undergo cardiac surgery has more risk than others, because of specific cardiovascular effects of the anesthetic drugs and the preoperative state of these patients, so the hemodynamic stability is very important in these patients. It seems that midazolam have less cardiovascular side effects than thiopentone. In this study, the effects of mid...
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عنوان ژورنال:
- British journal of anaesthesia
دوره 49 3 شماره
صفحات -
تاریخ انتشار 1977